(In)Distinctive Role of Long Non-Coding RNAs in Common and Rare Ovarian Cancers

Dr Maja Sabol and Dr Petar Ozretić from the Laboratory for Hereditary Cancer, Division of Molecular Medicine, Ruđer Bošković Institute, HR-10000 Zagreb, Croatia have published a collaborative review article focusing on the different aspects of long non-coding RNAs (lncRNAs) in common and rare ovarian cancers.

Ovarian cancers are the most lethal form of gynecological tumors. Rare ovarian cancers have distinct molecular characteristics, prognosis, and therapeutic approaches. Both common and rare ovarian malignancies mostly share the same problem: late diagnosis due to the lack of specific symptoms.

Therefore, there is a perpetual need to discover better diagnostic, prognostic, and predictive biomarkers, as well as new therapeutic approaches. In recent years, lncRNAs have gained widespread attention because of their important role in various biological pathways. They have multiple mechanisms of action with an important role in many cellular processes related to the development and progression of ovarian cancer.

Click here to read the full review article.